IMR Press / FBL / Volume 19 / Issue 8 / DOI: 10.2741/4289

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Id transcriptional regulators in adipogenesis and adipose tissue metabolism

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1 Department of Biochemistry and Molecular Biology, Molecular Oncology and Biomarkers Program, Georgia Regents University Cancer Center, Georgia Regents University, Room-CN3150, 1410 Laney Walker Blvd., Augusta, GA 30912, USA
Front. Biosci. (Landmark Ed) 2014, 19(8), 1386–1397; https://doi.org/10.2741/4289
Published: 1 June 2014
Abstract

Id proteins (Id1-Id4) are helix-loop-helix (HLH) transcriptional regulators that lack a basic DNA binding domain. They act as negative regulators of basic helixloop-helix (bHLH) transcription factors by forming heterodimers and inhibit their DNA binding and transcriptional activity. Id proteins are implicated in the regulation of various cellular mechanisms such as cell proliferation, cellular differentiation, cell fate determination, angiogenesis and tumorigenesis. A handful of recent studies also disclosed that Id proteins have critical functions in adipocyte differentiation and adipose tissue metabolism. Here, we reviewed the progress made thus far in understanding the specific functions of Id proteins in adipose tissue differentiation and metabolism. In addition to reviewing the known mechanisms of action, we also discuss possible additional mechanisms in which Id proteins might participate in regulating adipogenic and metabolic pathways. 

Keywords
WAT
BAT
Thermogenesis
Insulin Sensitivity
Lipid Metabolism
Review
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