IMR Press / FBL / Volume 19 / Issue 8 / DOI: 10.2741/4282

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Neuronal oscillations in Parkinson's disease
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1 Department of Neurosurgery, Wake Forest University
2 Virginia Tech Carilion Research Institute and Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University
Academic Editor:Gaetano Romano
Front. Biosci. (Landmark Ed) 2014, 19(8), 1291–1299; https://doi.org/10.2741/4282
Published: 1 June 2014
(This article belongs to the Special Issue Parkinsons disease)
Abstract

Parkinson's Disease (PD), characterized by tremor, rigidity, and bradykinesia, is one of the most prevalent neurodegenerative disorders in the world. The pathological hallmark of PD is the loss of dopaminergic cells in the substantia nigra and other brain regions. The pathophysiological mechanisms by which dopaminergic cell loss leads to the motor manifestations of PD are yet to be fully elucidated. A growing body of evidence has revealed abnormal neuronal oscillations within and between multiple brain regions in PD. Unique oscillatory patterns are associated with specific motor abnormalities in PD. Therapies, such as dopaminergic medication and deep brain stimulation that disrupt these abnormal neuronal oscillatory patterns produce symptomatic improvement in PD patients. These findings emphasize the importance of abnormal neuronal oscillations in the pathophysiology of PD, making the disruption of these oscillatory patterns a promising target in the development of effective PD treatments.

Keywords
Neuron
Oscillation
Brain stimulation
Bradykinesi
Parkinson’s disease
Review
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