IMR Press / FBL / Volume 19 / Issue 8 / DOI: 10.2741/4279

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The role of invariant NKT cells in organ-specific autoimmunity
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1 Experimental Diabetes Unit, Diabetes Research Institute, Department of Immunology,Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
Academic Editor:Antonio Cava
Front. Biosci. (Landmark Ed) 2014, 19(8), 1240–1250; https://doi.org/10.2741/4279
Published: 1 June 2014
(This article belongs to the Special Issue An update on the pathogenesis of immune dysregulation in autoimmunity)
Abstract

Invariant NKT cells (iNKT) represent a unique subset of innate lymphocytes that play a dual role and exert a pro-inflammatory function and also a tolerogenic function that is crucial to maintain T cell tolerance and prevent autoimmune diseases like Multiple Sclerosis, Type 1 Diabetes, Rheumatoid Arhritis and Systemic Lupus Erithematosus (SLE). Although a large body of evidence indicated that iNKT cells are instrumental to counter-regulate T cell-mediated autoimmune diseases, there is still some controversy on whether iNKT cells can actively induce immunosuppression and directly dampen T cell autoimmunity. Moreover, the recent discovery of a distinct iNKT cell subset, the iNKT17 cells, with strong adjuvant and pro-inflammatory function raised the question on what is the role of NKT17 cells in the pathogenesis of autoimmune diseases. Here, we review the current knowledge on iNKT cell biology and focus our attention on the possible mechanism of action and final effect of the different iNKT cell subsets in the pathogenesis of T cell-mediated autoimmune diseases.

Keywords
Review
Natural Killer T cells
Autoimmune diseases
Immune Tolerance
Dendritic Cells
Cytokines
Review
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