IMR Press / FBL / Volume 19 / Issue 8 / DOI: 10.2741/4278

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Lung tissue engineering
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1 Center for Regenerative Medicine, Department of Surgery, Massachusetts General Hospital, Boston, MA USA
2 Department of Surgery, Washington University in St. Louis, St. Louis, MO USA
Academic Editor:Alexander Sasha Krupnick
Front. Biosci. (Landmark Ed) 2014, 19(8), 1227–1239; https://doi.org/10.2741/4278
Published: 1 June 2014
(This article belongs to the Special Issue Lung tissue engineering)
Abstract

Lung tissue engineering is an emerging field focused on the development of lung replacement devices and tissue to treat patients with end stage lung disease. Microfluidic based lung assist devices have been developed that have biomimetically designed vascular networks that achieve physiologic blood flow. Gas exchange in these devices occurs across a thin respiratory membrane. Designed for intrathoracic implantation as a bridge to transplant or destination therapy, these lung assist devices will allow ambulation and hospital discharge for patients with end stage lung disease. Decellularized lungs subsequently recellularized with epithelial and endothelial cells have been implanted in small animal models with demonstration of initial gas exchange. Further development of these tissues and scaling to large animal models will validate this approach and may be an organ source for lung transplantation. Initial clinical success has been achieved with decellularized tracheal implants using autologous stem cells. Development of microfluidic lung models using similar architecture to the lung assist device technology allows study of lung biology and diseases with manipulation of lung cells and respiratory membrane strain.

Keywords
Tissue Engineering
Scaffold
Decellularize
Biomimetic
Vascular Network
Trachea
Review
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