IMR Press / FBL / Volume 19 / Issue 7 / DOI: 10.2741/4267

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Resveratrol in epilepsy: preventive or treatment opportunities?
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1 Deparment of Pharmacology and Medical Chemistry. Faculty of Pharmacy School of Pharmacy, Institute of Biomedicine (IBUB), Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED). University of Barcelona. 08028 Barcelona, Spain
2 Institute of Research in Biomedical Sciences (IICB), CUCS, University of Guadalajara, Sierra Mojada No. 950, Col. Independencia, Guadalajara, 44340 Jalisco, México
3 Laboratory of Neural Development and Regeneration, Institute of Neurobiology, Department of Cellular and Molecular Biology, CUCBA, University of Guadalajara, camino Ing. R. Padilla Sánchez, 2100, Las Agujas, Zapopan, 44600 Jalisco, México
4 Department of Environmental Sciences, Institute of Neurosciences, CUCBA, University of Guadalajara, 45100 Jalisco, México
5 Department of Basic Research, National Institute of Geriatrics (INGER), Periférico Sur No. 2767, Col. San Jerónimo Lídice, Deleg. Magdalena Contreras, 10200 México, D.F., México
Academic Editor:Antoni Camins
Front. Biosci. (Landmark Ed) 2014, 19(7), 1057–1064; https://doi.org/10.2741/4267
Published: 1 June 2014
(This article belongs to the Special Issue Current advances in epilepsy and neurodegeneration)
Abstract

Resveratrol has been extensively investigated and has been demonstrated to have antioxidant properties, cancer chemopreventive activity, and the capacity to modulate the hepatic synthesis of triglycerides and cholesterol, among others well established actions. A noteworthy feature of resveratrol is its ability to cross the blood-brain barrier and to exhibit neuroprotective actions, mainly by their capacity to regulate redox pathways as well as the Sirtuin (SIRT) system, which in turn modulates gene transcription, controlling inflammation and apoptosis in the brain. Lately, evidence is accumulating with respect to the synergic effect of resveratrol with antiepileptic drugs and also its antiepileptic activity in various models of seizures. We discuss here recent evidence that strongly suggests that resveratrol acts as an anticonvulsant agent and could be a very effective method for reducing damage in neural tissue and even for preventing seizure development in coadjuvant antiepileptic therapy.

Keywords
Resveratrol
Epilepsy Model
Nutraceutic
Neuroprotection
Review
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