IMR Press / FBL / Volume 19 / Issue 4 / DOI: 10.2741/4234

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Review
The role of PGRN in musculoskeletal development and disease
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1 Department of Orthopaedic Surgery, New York University Medical Center, New York, NY, 10003, USA
2 Ortopedicum Orthopaedic Surgery Clinic, Krakow, Poland
3 Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Front. Biosci. (Landmark Ed) 2014, 19(4), 662–671; https://doi.org/10.2741/4234
Published: 1 January 2014
Abstract

Progranulin (PGRN) is a growth factor that has been implicated in wound healing, inflammation, infection, tumorigenesis, and is most known for its neuroprotective and proliferative properties in neurodegenerative disease. This pleiotropic growth factor has been found to be a key player and regulator of a diverse spectrum of multisystemic functions. Its critical anti-inflammatory role in rheumatoid arthritis and other inflammatory disease models has allowed for the propulsion of research to establish its significance in musculoskeletal diseases, including inflammatory conditions involving bone and cartilage pathology. In this review, we aim to elaborate on the emerging role of PGRN in the musculoskeletal system, reviewing its particular mechanisms described in various musculoskeletal diseases, with special focus on osteoarthritis and inflammatory joint disease pathomechanisms and potential therapeutic applications of PGRN and its derivatives in these and other musculoskeletal diseases.


Keywords
Progranulin
PGRN
Growth factor
Disintegrin
Review
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