IMR Press / FBL / Volume 19 / Issue 2 / DOI: 10.2741/4204

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
The triple power of D³: protein intrinsic disorder in degenerative diseases
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1 Department of Molecular Medicine, USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA
2 Institute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia
Academic Editor:Batia Kaplan
Front. Biosci. (Landmark Ed) 2014, 19(2), 181–258; https://doi.org/10.2741/4204
Published: 1 January 2014
(This article belongs to the Special Issue Protein deposition diseases: pathology and micro-analytical methods)
Abstract

This review is an update of an article published four years ago (Uversky V.N. (2009) Intrinsically disordered proteins in neurodegenerative diseases: another illustration of the D² concept. Frontiers in Bioscience 14, 5188-5238). The major goal of this review is to show the interconnections between intrinsically disordered proteins (IDPs) and human neurodegeneration. This brings to existence a new D³ concept: protein intrinsic Disorder in neuroDegenerative Diseases. An important aspect of the D³ concept is that it deals with three D³'s, emphasizing that intrinsically Disordered proteins are abundantly found in various neuroDegenerative Diseases (the first D³), that these IDPs provoke neuroDegeneration due to their Dysfunctionality (the second D³), and that neuroDegeneration-related IDPs are often controlled by other Disordered proteins (the third D³).


Keywords
Neurodegenerative disease
intrinsically disordered protein
protein folding
protein misfolding
protein aggregation
protein-protein interaction
proteinfunction
protein dysfunction
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