IMR Press / FBL / Volume 19 / Issue 1 / DOI: 10.2741/4203

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Review
Bone marrow stromal cells in the pathogenesis of acute myeloid leukemia
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1 Charite University School of Medicine, Labor Berlin, Department of Hematology and Oncology, Berlin, Germany
Front. Biosci. (Landmark Ed) 2014, 19(1), 171–180; https://doi.org/10.2741/4203
Published: 1 January 2014
Abstract

Acute myeloid leukemia (AML) is clonal disorder affecting pluripotent stem cell and characterized by ineffective hematopoiesis. Genetic abnormalities in a progenitor cells is thought to lead to uncontrolled growth of leukemia cells. In addition, in the last years, it has been clearly recognized that the hematopoietic microenvironment (HM) plays an important role in the pathogenesis of AML. The HM can regulate hematopoiesis by interacting directly with HC and/or by secreting regulatory molecules that exert a positive or negative influence on the growth of HC. Stromal elements are important in the homing of immature HC or hematopoietic stem cells. Several studies propose that important quantitative and functional alterations are present in the BMSC of AML patients. AML may arise in the setting of an abnormal HM, resulting in the generation of multiple populations with varying initiation event. Dysfunction of HM may contribute to leukemia by supplying abundant growth factors that promote proliferation and/or inhibit apoptosis. Recent discoveries utilizing mouse models showed that genetic alteration in cells of HM can induce AML.


Keywords
Hematopoietic microenvironment
Bone marrow niches
Mesenchymal stromal cells
Acute myeloid leukemia
Review
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