IMR Press / FBL / Volume 18 / Issue 3 / DOI: 10.2741/4166

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Combined DCE and DW-MRI in the diagnosis of benign and malignant tumors of the tongue

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1 Deportment of Radiolog, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2 Engineering Research Center of Digital Medicine, Ministry of Education, Department of Orthopaedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Academic Editor:Jie Zou
Front. Biosci. (Landmark Ed) 2013, 18(3), 1098–1111;
Published: 1 June 2013
(This article belongs to the Special Issue Immunoregulation and inflammatory disease)

The combination of dynamic contrast-enhanced (DCE) and diffusion-weighted (DW)-MRI adds important information to the findings obtained through conventional spin echo MRI. We aimed to determine the value of combined DW- and DCE-MRI in distinguishing benign from malignant tumors of the tongue and mouth floor. The apparent diffusion coefficient (ADC) maps were constructed, and the ADC values of the lesions were calculated from DW-MRI. The slopes were derived from time-intensity curves (TICs) from DCE-MRI. The ADC map for malignant tumors was lower compared with the benign lesions. The slope in the malignant tumors was significantly greater compared with the benign lesions. In malignant tumors, the ADCb=500 threshold of < 1.43×10-3 mm2/s yielded a sensitivity, specificity, and accuracy of 74.6%, 83.3%, and 79.7%, respectively. For benign lesions, a slope threshold of <38.6 yielded a sensitivity, specificity, and accuracy of 80.3%, 74.5%, and 77.9%, respectively. Combined DCE- and DW-MR imaging may provide valuable information that allows for the differentiation between benign lesions and malignant tumors of the tongue and mouth floor.

Diffusion; Dynamic; enhancement; MRI
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