IMR Press / FBL / Volume 18 / Issue 2 / DOI: 10.2741/4138

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Tendon-derived stem cells as a new cell source for tendon tissue engineering

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1 Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China
Academic Editor:Xu Jin
Front. Biosci. (Landmark Ed) 2013, 18(2), 756–764; https://doi.org/10.2741/4138
Published: 1 January 2013
(This article belongs to the Special Issue The dual role of ERK signaling in the apoptosis of neurons)
Abstract

Tendon injuries are very common in occupational and athletic settings, and the elderly population. Tendons repair and regenerate slowly and inefficiently in vivo after injury. The limited ability of tendons to self-repair and the general inefficiency of current treatment strategies have intensified the need for an effective therapeutic approach. Tendon-derived stem cells (TDSCs) have recently been identified within tendon tissues. TDSCs exhibit universal stem cell characteristics, such as clonogenicity, a high proliferative capacity, multi-differentiation potential, nonimmunogenicity, and immunosuppression. As a result, implanting TDSCs at damaged sites within tendons may be an effective way for tendon regeneration. This review summarizes the properties of TDSCs and discusses the advantages of its use in tendon tissue engineering.

Keywords
Tendon
Tendon-Derived
Stem Cells
TDSCS
Regeneration
Tissue Engineering
Review
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