IMR Press / FBL / Volume 18 / Issue 2 / DOI: 10.2741/4119

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Ovarian cancer as a genetic disease
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1 Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland
2 College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, Zwirki i Wigury 93, 02-089 Warsaw, Poland
3 Department of Imunobiology of Reproduction, Institute of Biology and Immunology of Reproduction, Sofia, Bulgaria
4 Department of Human and Animal Physiology, Faculty of Biology, St. Kliment Ohridski, University of Sofia, 1164 Sofia, Bulgaria
5 Department of Clinical and Experimental Physiology, Medical University of Warsaw, Warsaw, Poland
6 Department and Clinic of Urology, Faculty of Medical Sciences, Medical University of Warsaw, Warsaw, Poland
7 Department of Otolaryngology, Medical University of Warsaw, Stepinska 19/25, 00-739 Warsaw, Poland
Academic Editor:Anna Czarnecka
Front. Biosci. (Landmark Ed) 2013, 18(2), 543–563; https://doi.org/10.2741/4119
Published: 1 January 2013
(This article belongs to the Special Issue Frontiers in molecular medicine)
Abstract

Ovarian cancer is characterized by the highest mortality rate among gynecologic malignancies. Therefore, there is a growing need for innovative therapies and techniques for monitoring and prevention of this disease. The exact cause of most ovarian tumors usually remains unknown. Ovarian cancer is believed to be caused by a range of different variables. This review is an attempt to summarize some genetic factors involved in the disruption of certain signaling pathways responsible for ovarian tumor transformation and development. Those factors considerably contribute to accurate diagnostics, treatment and prognosis in ovarian cancer.

Keywords
Ovarian cancer
Cancerogenesis
Signaling pathway
BRCA1
BRCA2
TP53
PIK3CA
Review
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