IMR Press / FBL / Volume 18 / Issue 1 / DOI: 10.2741/4095

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Strong correlation between diet and development of colorectal cancer
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1 Department of Surgery, General Surgery and Breast Unit, University of Catania, Azienda Ospedaliero-Universitaria, Policlinico Vittorio Emanuele, via S. Sofia, 78, 95123 Catania, Italy
2 Department of Surgery, Transplantation and Advanced Technologies, University of Catania, Italy
3 Division of Laparoscopic and Bariatric Surgery, University of Maryland, Baltimore, MD, USA
4 Department of Surgery, Digestive Surgery Unit, University of Catania, Azienda Ospedaliero-Universitaria Policlinico, Vittorio Emanuele, via S. Sofia, 78, 95123 Catania, Italy
5 Scientific Direction, National Cancer Institute, I.R.C.C.S., via Franco Gallini 2, 33081 Aviano (PN), Italy
6 Department of Medical Oncology, National Cancer Institute, I.R.C.C.S., via Franco Gallini 2, 33081 Aviano (PN), Italy
Academic Editor:Fabio Galvano
Front. Biosci. (Landmark Ed) 2013, 18(1), 190–198; https://doi.org/10.2741/4095
Published: 1 January 2013
(This article belongs to the Special Issue Dietary approaches to prevent chronic-degenerative diseases)
Abstract

Multiple factors have been described among the causes of non-hereditary colorectal cancer. In Western countries, the most common risk factors include upper- middle socioeconomic status and dietary regimens rich in proteins and animal fats. High consumption of red meats, smoked foods, cold cuts, or canned foods is believed to contribute to carcinogenesis as they directly affect epithlial turnover and cause metabolism of biliary acids. Dietary fibers have protective effects in that they capture the fats and biliary acids, thereby inhibiting their activity. Tobacco smoking acts both locally and systemically on the colorectal mucosa through the production of carcinogenic agents. Finally, the action of alcohol, in association with nicotine addiction, also increases the risk of developing colorectal tumors. Knowledge of dietary and environmental factors is of paramount importance in implementing preventive strategies for colorectal cancer.

Keywords
Colorectal cancer
Dietary habits
Fibers Intake
Folate
Meat Intake
Methylation
Obesity
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