IMR Press / FBL / Volume 17 / Issue 4 / DOI: 10.2741/3997

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Anti-apoptotic effects of melatonin in retinal pigment epithelial cells
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1 Department of Ophthalmology, Shanghai Jiaotong University Affiliated First People's Hospital, 200080 Shanghai, China

Academic Editor: Jie Zou

Front. Biosci. (Landmark Ed) 2012, 17(4), 1461–1468;
Published: 1 January 2012
(This article belongs to the Special Issue Immunoregulation and inflammatory disease)

Recent studies have revealed that melatonin exerts strong anti-apoptotic effects. Retina secretes melatonin, and melatonin receptors are distributed in almost all the layers of retina, including the layer of retinal pigment epithelial (RPE) cells. However, it is not known whether melatonin inhibits apoptosis through its anti-oxidant effects and how it works in RPE cells. Here, we show that melatonin decreases H2O2-induced apoptosis in RPE cells partially through protection of mitochondria. Melatonin decreased reactive oxygen species in mitochondria and mitochondrial DNA damage, alleviated structural damage and inhibited cytochrome C release.

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