IMR Press / FBL / Volume 17 / Issue 3 / DOI: 10.2741/3968

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Mitotic checkpoint control and chromatin remodeling
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1 Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987
Academic Editor:Min-Hao Kuo
Front. Biosci. (Landmark Ed) 2012, 17(3), 976–983; https://doi.org/10.2741/3968
Published: 1 January 2012
(This article belongs to the Special Issue Chromatin and cell cycle)
Abstract

In order to maintain chromosomal stability during cell division, eukaryotic cells have evolved a number of surveillance mechanisms termed checkpoints. These checkpoints monitor the completion of essential molecular and cellular processes of one stage before entering another. The spindle checkpoint watches the bi-orientation attachment of spindle microtubules to all condensed chromosomes before initiation of nuclear division during mitosis. Histones are subject to a number of post-translational modifications during the cell cycle, which may in turn modify or facilitate cell cycle progression. Recent studies suggest that mitotic proteins including Bub1 and Sgo1 that are involved in the spindle checkpoint also play a major role in the regulation of histone modifications and chromatin remodeling. This mini-review summarizes emerging information about the new role of spindle checkpoint proteins in chromatin remodeling.

Keywords
Mitotic Checkpoint
Chromatin Remodeling
Sgo1
mitosis
Bub1
Review
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