IMR Press / FBL / Volume 17 / Issue 2 / DOI: 10.2741/3953

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Tissue specific epigenetic differences in CRH gene expression
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1 Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, NSW 2305, Australia
2 Department of Pathophysiology, Second Military Medical University, Shanghai 200433, China
3 Department of Physiology, Second Military Medical University, Shanghai 200433, China
Academic Editor:Richard Nicholson
Front. Biosci. (Landmark Ed) 2012, 17(2), 713–725; https://doi.org/10.2741/3953
Published: 1 January 2012
(This article belongs to the Special Issue Corticotrophin releasing hormone)
Abstract

Corticotropin Releasing Hormone (CRH), a 41-amino acid peptide, is a major regulator of hypothalamic-pituitary-adrenal axis function. CRH also has important roles in several processes pertaining to pregnancy and parturition, including being a possible regulator of gestational length and predictor of pre-term birth. Regulation of the CRH promoter exhibits some tissue-specificities, the most well characterized example being glucocorticoids, which can stimulate placental CRH production but suppress hypothalamic CRH. In the last decade there has been growing interest in the role of epigenetic regulation of gene expression. Modification of the structure of chromatin is an example of epigenetic change affecting gene expression. We have found that inhibition of histone deacetylases results in an increase in CRH expression in the AtT20 pituitary cell line, but a decrease in CRH expression in the placenta. In this paper we review tissue specific differences in CRH gene expression, and discuss how epigenetic chromatin modification mechanisms can relate to tissue specific differences in expression of CRH.

Keywords
Epigenetic
Placenta
HPA axis
HDAC
TSA
Review
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