IMR Press / FBL / Volume 17 / Issue 2 / DOI: 10.2741/3952

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The role of microRNAs in glioma initiation and progression
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1 Departments of Microbiology, University of Virginia, Charlottesville, VA, USA
2 Departments of Biochemistry, University of Virginia, Charlottesville, VA, USA
3 Departments of Neurology, University of Virginia, Charlottesville, VA, USA
Academic Editor:Manuel Verdugo
Front. Biosci. (Landmark Ed) 2012, 17(2), 700–712;
Published: 1 January 2012
(This article belongs to the Special Issue Initiation of DNA replication)

micoRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by targeting the mRNAs of a large number of human genes. Gliomas are the most common and deadly primary human brain tumors and are thought to originate from transformed stem-like cells (GSCs). microRNAs are frequently deregulated in cancer and gliomas and their deregulation has been associated with various aspects of glioma pathobiology. The present review summarizes the published literature on the role of miRNAs in gliomas with a focus on their role in GSCs.

Stem Cells
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