IMR Press / FBL / Volume 17 / Issue 1 / DOI: 10.2741/3933

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Review
(Pro)renin receptor and prorenin: their plausible sites of interaction
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1 Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh
2 United Graduate School of Agricultural Science, Japan
3 Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan
Front. Biosci. (Landmark Ed) 2012, 17(1), 389–395; https://doi.org/10.2741/3933
Published: 1 January 2012
Abstract

Before discovery of (pro)renin receptor, prorenin was regarded as a source of renin and probable diagnostic marker for diabetic nephropathy/Wilms' tumor. It is now considered that prorenin can perform renin activity by binding to (P)RR and binding mechanism of (pro)renin to (P)RR was indicated in many in vitro studies. Considering the physiological importance and pathological involvement of (P)RR, it is indeed a demand of time to determine the three dimensional structure of (P)RR to design (P)RR blocker(s) effective for (pro)renin. It may also facilitate to explain the incompatible data about the effective application of decoy peptide as (P)RR blocker. So far, studies have discussed the bindings of (pro)renin to (P)RR using peptides mimicking the structures of ligands (e.g., the decoy including "handle" region peptide, the "hinge" peptide etc). In this review, the binding mechanism of ligands has been highlighted from the structural aspect of (P)RR using several anti-(P)RR antibodies designed from the primary structure of (pro)renin receptor. Therefore, this review would give us a clue regarding the plausible binding region(s) for prorenin in the (P)RR.

Keywords
Binding kinetics
Decoy peptide
Prorenin
(Pro)renin receptor
(P)RR
Surface plasmon resonance
Review
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