IMR Press / FBL / Volume 17 / Issue 1 / DOI: 10.2741/3930

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
WW domain-containing proteins: retrospectives and the future
Show Less
1 The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel
Academic Editor:Nan-Shan Chang
Front. Biosci. (Landmark Ed) 2012, 17(1), 331–348; https://doi.org/10.2741/3930
Published: 1 January 2012
(This article belongs to the Special Issue WW domain proteins - A 10-year retrospective for WWOX)
Abstract

WW domains are protein modules that mediate protein-protein interactions through recognition of proline-rich peptide motifs (PRM) and phosphorylated serine/threonine-proline sites. WW domains are found in many different structural and signaling proteins that are involved in a variety of cellular processes, including RNA transcription and processing, protein trafficking and stability, receptor signaling, and control of the cytoskeleton. WW domain-containing proteins and complexes have been implicated in major human diseases including cancer as well as in major signaling cascades such as the Hippo tumor suppressor pathway, making them targets for new diagnostics and therapeutics. In this review, we discuss how WW domains provide versatile platforms that link individual proteins into physiologically important networks and the indispensible role of WW domain-containing proteins in biology and pathology, especially tumorogenesis.

Keywords
WW domain
WWOX
YAP
ITCH
AIP4
Hippo Pathway
Tumor Suppressor
Tumorigenesis
Review
Share
Back to top