Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
The purpose of this article is to provide an overview on the regulation of transcription in cancer cells. We describe here standard mechanisms of transcription in eukaryotic cells, an influence of common promoter polymorphisms contributing to malignant progression and DNA methylation as significant aspect of gene regulation. We also described transcription factors mechanism of action, and how their alteration can result in cancer.