IMR Press / FBL / Volume 17 / Issue 1 / DOI: 10.2741/3927

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Hepatitis C virus' initial encounters: mechanisms of innate immunity
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1 H. Lee Moffitt Cancer Center, Department of Immunology, 12902 Magnolia Drive,Tampa, FL 33612
Academic Editor:Maysaa El Sayed Zaki
Front. Biosci. (Landmark Ed) 2012, 17(1), 281–299; https://doi.org/10.2741/3927
Published: 1 January 2012
(This article belongs to the Special Issue Molecular bases and therapeutic options of hepatitis viruses)
Abstract

HCV is a single-stranded RNA virus that affects approximately 210 million people worldwide causing chronic disease in 80% of those infected. With the development of new models of study, and a better understanding of the innate immune response, the way this virus induces and evades an immune response at the beginning of the infection has started to be recognized as a critical stage for the development of the chronic state. Still, even with so much information, the question remains as to how the virus establishes itself successfully in the host; a critical question that can lead to life-saving answers. In this review we aim to understand the initial interaction of the virus with its host based on the current literature that links innate immunity and HCV's effects over it.

Keywords
HCV
Innate Immunity
Dendritic Cells
TLR3
RIG-I
Interferon Response
Review
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