IMR Press / FBL / Volume 17 / Issue 1 / DOI: 10.2741/3913

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
The hematopoietic stem cell niche
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1 Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA, 02114, USA
2 Harvard Stem Cell Institute, 42 Church Street, Cambridge, MA, 02138, USA
3 Department of Stem Cell and Regenerative Biology, Harvard University, Divinity Avenue, Cambridge, MA, 02138
Academic Editor:Sophia Khaldoyanidi
Front. Biosci. (Landmark Ed) 2012, 17(1), 30–39; https://doi.org/10.2741/3913
Published: 1 January 2012
(This article belongs to the Special Issue Stem cell microenvironment)
Abstract

Hematopoietic stem cells (HSCs) possess the ability to self-renew and to differentiate to mature progeny along multiple different hematopoietic lineages. The function of HSCs depends upon the signals from surrounding cells found within the highly specialized microenvironment termed the hematopoietic stem cell niche. Understanding and exploiting the HSC niche is a goal of basic scientists and clinicians alike. Recent studies have focused on defining the cellular components and molecular factors critical to this microenvironment. Here we review recent findings, discuss unresolved questions, and examine the clinical implications of our current knowledge of the HSC niche.

Keywords
Hematopoietic Stem Cells
Niche
Osteoblasts
Endothelial Cells
Review
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