IMR Press / FBL / Volume 17 / Issue 1 / DOI: 10.2741/3911

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
MDA-9/syntenin: a positive gatekeeper of melanoma metastasis
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1 Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298
2 INSERM U583, Montpellier, France
3 VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298
4 VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298
Front. Biosci. (Landmark Ed) 2012, 17(1), 1–15;
Published: 1 January 2012

Melanoma differentiation associated gene-9 (MDA-9), synonymous with syntenin, is an adapter protein that provides a central role in regulating cell-cell and cell-matrix adhesion. MDA-9/syntenin transduces signals from the cell-surface to the interior through its interaction with a plethora of additional proteins and actively participates in intracellular trafficking and cell-surface targeting, synaptic transmission, and axonal outgrowth. Recent studies demarcate a seminal role of MDA-9/syntenin in cancer metastasis. In the context of melanoma, MDA-9/syntenin functions as a positive regulator of melanoma progression and metastasis through interactions with c-Src and promotes the formation of an active FAK/c-Src signaling complex leading to NF-κB and matrix metalloproteinase (MMP) activation. The present review provides a current perspective of our understanding of the important features of MDA-9/syntenin and its significant role in tumor cell metastasis with special focus on molecular mechanism of action.

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