IMR Press / FBL / Volume 16 / Issue 8 / DOI: 10.2741/3896

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Effect of thymectomy on cellular immune function
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1 Department of Pediatrics, Shanghai JiaoTong University Affiliated Shanghai Children’s Medical Center, Shanghai 200127, China
2 Department of Pediatric Cardiothoracic Surgery, Shanghai JiaoTong University Affiliated Shanghai Children’s Medical Center, Shanghai 200127, China
3 Department of Pediatric Cardiology, Shanghai JiaoTong University Affiliated Xinhua Hospital, Shanghai 200092, China
Academic Editor:Jie Zou
Front. Biosci. (Landmark Ed) 2011, 16(8), 3036–3042; https://doi.org/10.2741/3896
Published: 1 June 2011
(This article belongs to the Special Issue Immunoregulation and inflammatory disease)
Abstract

The present study was conducted to evaluate the effect of thymectomy during open heart surgery on immunological function of T lymphocytes in the treatment of children with congenital heart disease (CHD). No significant difference was found in the sjTREC level between pre-thymectomy and post- thymectomy in the non-thymectomy group and the small partial resection group (P>0.05) However, the sjTREC level decreased from the pre-surgical level at 1 month (P<0.01) and 12 months (P<0.01) in the sub-total resection group. No differences were found in proportions of CD3, CD4 and CD8 lymphocytes, proliferative ability of lymphocytes and expression of IL-2, IL-4 and IFN-γ after surgery between controls and three groups of patients (P>0.05). In the sub-total resection group, respiratory infection frequency (4.7±1.7 times) did not differ significantly from control group one year after surgery (P>0.05); however, mean days of anti-infection were significantly increased (P less than 0.01). In conclusion, sub-total thymectomy leads to a decrease in the sjTREC level in CHD children, whereas the function of peripheral mature T lymphocytes is normal.

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