IMR Press / FBL / Volume 16 / Issue 8 / DOI: 10.2741/3888

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Molecular regulation of the intestinal epithelial barrier: implication in human diseases
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1 Department of Surgery, Shanghai JiaoTong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China
Academic Editor:Jie Zou
Front. Biosci. (Landmark Ed) 2011, 16(8), 2903–2909;
Published: 1 June 2011
(This article belongs to the Special Issue Immunoregulation and inflammatory disease)

Intestinal barrier dysfunction is implicated in the development of various clinical diseases. While the study of intestinal barrier function has traditionally emphasized the impact of intestinal microflora and bacteria, the rapid development of molecular and cellular techniques has helped the recent transition of the field to the molecular regulation of the intestinal epithelial barrier. In this review, we summarized several aspects of recent progress on the molecular regulation of the intestinal epithelial barrier, ranging from the extrinsic factors such as probiotics, intrinsic protein effectors including the tight junction proteins, intestinal alkaline phosphatase and protein phosphatase 2A, to intestinal cell subsets such as intestinal intraepithelial lymphocytes and intestinal stem cells. Further investigations into the detailed mechanisms underlying the molecular regulation of the intestinal epithelial barrier will enable our manipulation of the factors and cell subsets involved to develop effective approaches to treat intestinal barrier dysfunction associated diseases.

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