IMR Press / FBL / Volume 16 / Issue 7 / DOI: 10.2741/3878

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Omega-3 polyunsaturated fatty acids in the brain: metabolism and neuroprotection
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1 State Key Laboratory of Medical Neurobiology, Anesthesiology Department of Huanshan Hospital, and Institute of Brain Sciences, Fudan University, Shanghai 200032, China
2 Department of Neurology and Center of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Academic Editor:Feng Zhang
Front. Biosci. (Landmark Ed) 2011, 16(7), 2653–2670;
Published: 1 June 2011

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are a group of essential fatty acids that serve as energy substrates and integral membrane components, and therefore play crucial roles in the maintenance of normal neurological function. Recent studies show that n-3 PUFAs display neuroprotective properties and exert beneficial effects on the cognitive function with aging. The brain's need of n-3 PUFAs is predominantly met by the blood delivery due to their limited synthesis in the brain. The present review focuses on the metabolism of n-3 PUFAs in the brain, including their accumulation and turnover. We also highlight the current understanding of the neuroprotective effects of n-3 PUFAs against cerebral ischemia and neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease.

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