IMR Press / FBL / Volume 16 / Issue 5 / DOI: 10.2741/3827

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis
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1 Wellcome Trust/Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
2 Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich, Norfolk NR4 7JT, UK

Academic Editors: Wen G Jiang, Richard Ablin

Front. Biosci. (Landmark Ed) 2011, 16(5), 1861–1872; https://doi.org/10.2741/3827
Published: 1 January 2011
(This article belongs to the Special Issue Bone metastasis, the molecular, cellular and clinical prospects)
Abstract

The human ADAMTS (a disintegrin and metalloproteinase with thrombospondin-like motifs) family of 19 secreted, multidomain proteolytic enzymes is involved in a wide range of biological processes including ECM assembly and degradation, hemostasis, organogenesis and the regulation of angiogenesis. Defects in certain family members give rise to inherited human genetic diseases, while aberrant expression of other ADAMTSs has been linked to the pathogenesis of arthritis and cancer. Several ADAMTSs act as tumor or metastasis suppressors whose functions are lost either by mutation or epigenetic silencing during tumor progression. This review looks in depth at the involvement of ADAMTSs as positive and negative mediators in cancer growth and spread.

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