IMR Press / FBL / Volume 16 / Issue 5 / DOI: 10.2741/3821

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
KSRP, many functions for a single protein
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1 Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
2 Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
3 RNA Technology Laboratory, Centro di Biotecnologie Avanzate, 16132 Genova, Italy
4 Universita’ degli Studi di Genova, Largo R. Benzi, 10, 16132 Genova, Italy
5 Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, California 92093-0648, USA
6 Division of Molecular Structure, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK

Academic Editors: Kotb Abdelmohsen, Songbi Chen

Front. Biosci. (Landmark Ed) 2011, 16(5), 1787–1796;
Published: 1 January 2011
(This article belongs to the Special Issue RNA binding proteins in disease)

KSRP is a single-strand nucleic acids binding protein that affects RNA fate at multiple levels. KSRP modular structure and its complex pattern of post-translational modifications underpin the interaction with a wide spectrum of RNA target sequences, as well as with other RNA-binding proteins and molecular adaptors. These interactions are important to the regulation of different steps of mRNA metabolism and, in turn, modulate several aspects of cellular proliferation and differentiation. In this review we will discuss in detail KSRP ability to i) promote decay of labile mRNAs interacting with some components of the mRNA decay machinery and ii) favor the maturation of a select group of microRNA precursors.

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