IMR Press / FBL / Volume 16 / Issue 4 / DOI: 10.2741/3784

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Regulation of resident and newcomer insulin granules by calcium and SNARE proteins
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1 Department of Biochemistry, Kyorin University School of Medicine, Mitaka, Tokyo 181-8611, Japan
Front. Biosci. (Landmark Ed) 2011, 16(4), 1197–1210; https://doi.org/10.2741/3784
Published: 1 January 2011
Abstract

Insulin, stored in large dense core granules, is biphasically exocytosed by glucose stimulation in pancreatic beta-cells. Several molecules, such as SNARE proteins, and Ca2+ ion are involved in the regulation of insulin exocytosis. Indeed, studies using gene targeting mice revealed critical roles of SNARE proteins and their accessory proteins, which may be associated with diabetes mellitus. In particular, the total internal reflection fluorescent (TIRF) imaging technique shed new light on the molecular mechanism of the insulin exocytotic process. In this review we discuss the mechanism of insulin exocytosis mainly from a point of view of imaging techniques.

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