IMR Press / FBL / Volume 16 / Issue 2 / DOI: 10.2741/3715

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Lymphangiogenesis and cancer metastasis
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1 Department of Surgery, Betsi Cadwaladr University Health Board Glan Clwyd Hospital, Rhyl, Denbighshire LL18 5UJ, UK. mahir.al-rawi@doctors.org.uk
2 Department of Surgery, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
Academic Editors:Wen G Jiang, Richard Ablin
Front. Biosci. (Landmark Ed) 2011, 16(2), 723–739; https://doi.org/10.2741/3715
Published: 1 January 2011
(This article belongs to the Special Issue Bone metastasis, the molecular, cellular and clinical prospects)
Abstract

Lymphangiogenesis remains a fascinating biological process that plays a crucial role in both normal tissue development and several lymphatic diseases. The last few years have witnessed a rapid progression in understanding the development and regulation of the lymphatic system which provided insight on several pathological processes including cancer lymphatic metastasis. Lymphatic vasculature serves as a major route for tumour metastasis. The dissemination of malignant cells to the regional lymph nodes is an early step in the progression of many solid tumours and is an important determinant of staging and prognosis. Lymphangiogenesis is thought to play a pivotal role for cancer cells to metastasis to the regional lymph nodes. Several human solid tumours are now considered to be lymphangiogenic i.e. they have the ability to induce their own lymphatic vessels to establish metastasis. Hence, targeting lymphangiogenesis by developing anti-lymphangiogenic agents might constitute a novel way to prevent lymphatic progression in some tumours. Here, we have reviewed the development of the lymphatic system, the regulation of lymphangiogenesis and explored its relation to several human cancers.

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