IMR Press / FBL / Volume 15 / Issue 2 / DOI: 10.2741/3642

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Aging and the control of human skin blood flow
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1 Department of Kinesiology, The Pennsylvania State University, Noll Laboratory, University Park, PA 16802, USA
2 Department of Biomedical Engineering, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
3 Graduate Physiology Program, The Pennsylvania State University, Noll Laboratory, University Park, PA 16802, USA
Academic Editor:Clark Blatteis
Front. Biosci. (Landmark Ed) 2010, 15(2), 718–739; https://doi.org/10.2741/3642
Published: 1 January 2010
(This article belongs to the Special Issue Frontiers in thermoregulation research)
Abstract

Human exposure to cold and heat stimulates cutaneous vasoconstriction and vasodilation via distinct sympathetic reflex and locally mediated pathways. The mechanisms mediating cutaneous vasoconstriction and vasodilation are impaired with primary aging, rendering the aged more vulnerable to hypothermia and cardiovascular complications from heat-related illness, respectively. This paper highlights recent findings discussing how age-related decrements in sympathetic neurotransmission contribute directly to thermoregulatory impairments, whereas changes in local intracellular signaling suggest a more generalized age-associated vascular dysfunction.

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