IMR Press / FBL / Volume 15 / Issue 1 / DOI: 10.2741/3624

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Expression of immune genes during metamorphosis of Xenopus: a survey

Show Less
1 Epigenomics Project, Genopole®, CNRS, Univ Evry, Tour Evry2 10eme 523 Terrasses de l'Agora, F-91034 Evry, France
2 CNRS UMR 8080, F-91405 Orsay, France
3 Laboratoire Developpement, Morphogenese et Evolution, Univ Paris Sud, F-91405 Orsay, France
Academic Editor:Jacques Robert
Front. Biosci. (Landmark Ed) 2010, 15(1), 348–358; https://doi.org/10.2741/3624
Published: 1 January 2010
Abstract

This review focuses on what is known about the immune transcriptome during metamorphosis of Xenopus laevis and Silurana (Xenopus) tropicalis. This subject is of importance to obtain a global understanding of the physiological changes operating during metamorphosis. In turn, a good knowledge of the physiology of amphibian metamorphosis may contribute to the fight against amphibian decline and help the development of alternative toxicologic assays. By examining what is known on the expression of innate and adaptive immune genes during metamorphosis, it becomes clear that our knowledge of the anatomy of the tadpole "immunome" is fragmentary. Since a wealth of data sits in cDNA sequences, I am making a first attempt to enrich our knowledge on this subject. I exemplify that mining EST data can rapidly provide us with the necessary tools to unravel the cross-talk between thyroid hormone signalling during metamorphosis and larval immune system changes.

Share
Back to top