IMR Press / FBL / Volume 14 / Issue 7 / DOI: 10.2741/3400

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis
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1 Department of Pediatrics Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
2 Department of Laboratory Medicine, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
3 Texas Children’s Liver Center, Department of Pediatrics/GI, Hepatology & Nutrition, Baylor College of Medicine, Houston, TX, USA
Academic Editor:Luis Alvarez
Front. Biosci. (Landmark Ed) 2009, 14(7), 2599–2630; https://doi.org/10.2741/3400
Published: 1 January 2009
(This article belongs to the Special Issue Biliary transport systems, nuclear receptors and liver disease)
Abstract

Inflammation-induced cholestasis (IIC) is a frequently occurring phenomenon. A central role in its pathogenesis is played by nuclear receptors (NRs). These ligand-activated transcription factors not only regulate basal expression of hepatobiliary transport systems, but also mediate adaptive responses to inflammation and possess anti-inflammatory characteristics. The latter two functions may be exploited in the search for new treatments for IIC as well as for cholestasis in general. Current knowledge of the pathogenesis of IIC and the dual role NRs in this process are reviewed. Special interest is given to the use of NRs as potential targets for intervention.

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