IMR Press / FBL / Volume 14 / Issue 7 / DOI: 10.2741/3388

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Life span of monocytes and platelets: importance of interactions
Show Less
1 Universitaet Muenster, Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Domagkstrasse 3a, 48149 Muenster, Germany
2 Dialyezentrum Nordhorn, Osnabrueckerstrasse 1, 48529 Nordhorn, Germany
Academic Editor:Andrea Doseff
Front. Biosci. (Landmark Ed) 2009, 14(7), 2432–2447;
Published: 1 January 2009
(This article belongs to the Special Issue Mechanisms of survival and cell death in leukocytes)

Monocytes interact and cross-talk with platelets in many settings including inflammation, hemeostasis, or vascular disorders. These interactions are important for the regulation of life span of both. During inflammatory diseases, there is a rapid targeting of monocytes and platelets to points of inflammation and endothelial injury where they lie side-by-side. Adherence between monocytes/macrophages (Mphi) and platelets occur in the vessel wall and atherosclerotic plaque, but it is also shown in the blood stream where it has been called platelet satellitism. This phenomenon has been attributed to thrombotic disorders such as stroke. Furthermore, we discovered consequences for leukocyte apoptosis after the interaction with platelets. Herein, we reviewed the complex mechanism and interactions regulating the life span of both types of blood cells. We also provide a distinct focus on apoptosis of platelets and Mphi.

Back to top