IMR Press / FBL / Volume 14 / Issue 5 / DOI: 10.2741/3341

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Proteomics/peptidomics tools to find CSF biomarkers for neurodegenerative diseases
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1 Institute of Neuroscience and Physiology, Department of Psychiatry and Neuochemistry, The Sahlgrenska Academy at Goteborg University, Sweden
2 Institute of Laboratory Medicine, Department of Clinical Chenistry and Transfusion Medicine, The Sahlgrenska Academy at Göteborg University, Sweden
Front. Biosci. (Landmark Ed) 2009, 14(5), 1793–1806;
Published: 1 January 2009

Neurodegenerative diseases are characterized by premature neuronal loss in specific brain regions. During the past decades our knowledge on molecular mechanisms underlying neurodegeneration has increased immensely and resulted in promising drug candidates that might slow down or even stop the neuronal loss. These advances have put a strong focus on the development of diagnostic tools for early or pre-clinical detection of the disorders. In this review we discuss our experience in the field of neuroproteomics/peptidomics, with special focus on biomarker discovery studies that have been performed on CSF samples from well-defined patient and control populations.

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