Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
This article focuses on cell-material interactions of neurons in the context of nerve regeneration and tissue engineering applications. In this review, the cellular and molecular environment of neurons is described in both the uninjured and injured tissue. The interactions between specific materials and neurons is explained, in addition to heterogeneous substrates and guiding scaffolds that are used experimentally.