IMR Press / FBL / Volume 14 / Issue 2 / DOI: 10.2741/3272

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Enhancing oxygen solubility using hemoglobin- and perfluorocarbon-based carriers
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1 Laboratoire de Bioingenierie et de Biophysique de l’Universite de Sherbrooke, Department of Chemical Engineering, Universite de Sherbrooke, 2500, boul. de l’Universite, Sherbrooke, Quebec, J1K 2R1, Canada
2 Research Centre on Aging, Institut universitaire de geriatrie de Sherbrooke, 1036, rue Belvedere sud, Sherbrooke, Quebec, J1H 4C4, Canada
Academic Editors:Patrick Vermette, Jonathan Lakey, Rennian Wang, Steven Paraskevas
Front. Biosci. (Landmark Ed) 2009, 14(2), 665–688;
Published: 1 January 2009

The objective of this paper is to review the properties of fluids capable to enhance oxygen transport and transfer and recent developments in this field. This paper reviews and compares two different approaches, which could be used to solve the important problem of oxygen supply in some cell and tissue cultures: 1) hemoglobin-based and 2) perfluorocarbon-based (PFC) oxygen carriers. Several types of modified hemoglobin-based oxygen carriers (HBOCs) and their preparation are reviewed, as well as advances in the field of PFC oxygen carriers. Finally, we highlight the advantages and pitfalls, when reported in the literature, associated with each technique.

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