IMR Press / FBL / Volume 14 / Issue 2 / DOI: 10.2741/3268

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Assembly and function of the natural killer cell immune synapse
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1 Department of Systemic Cell Biology, Max Planck Institute of Molecular physiology, Otto-Hahn-Str. 11, D-44227 Dortmund, Germany
Academic Editors:Alberto Boveris, Ana Navarro
Front. Biosci. (Landmark Ed) 2009, 14(2), 621–633;
Published: 1 January 2009
(This article belongs to the Special Issue Mitochondria: physiological function, signaling and oxidative damage)

During the natural killer (NK) cell immune response, cytoskeletal components, adhesion and signaling molecules and ligand-specific receptors are involved in the formation of the natural killer cell immune synapse (NK-IS), a highly organized supramolecular structure assembled at the interface of the interacting cells that regulates the NK cell activation and decides the target cell fate. In this review the current state on knowledge about the organization and physio-pathological function of the inhibitory, cytotoxic and activating NK-IS is presented. Moreover, it briefly summarizes microspectroscopy techniques suitable for live cell imaging of the dynamic biochemical processes, which achieve the coordinated NK cell immune responses.

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