IMR Press / FBL / Volume 14 / Issue 2 / DOI: 10.2741/3253

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Response and adaptation of skeletal muscle to denervation stress: the role of apoptosis in muscle loss
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1 Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
2 Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
Academic Editor:Yuefei Liu
Front. Biosci. (Landmark Ed) 2009, 14(2), 432–452;
Published: 1 January 2009
(This article belongs to the Special Issue Muscular adaptation to cellular stress)

Apoptosis is a well-conserved cellular destructive event which has been implicated in a variety of diseases such as cancers and neurodegenerative diseases. The comprehensive investigation of apoptosis has been emerged in the field of skeletal muscle biology. Results have been consistent in demonstrating the activation of apoptotic machinery in different pathologic and physiologic muscle atrophic conditions including muscle disuse, hindlimb unloading, muscle dystrophy, sarcopenia, and neuromuscular diseases. Together with the other identified muscle atrophy-related signaling mechanisms such as NFκB, FOXOs/MuRF1/MAFbx and ubiquitin-proteasome, apoptosis has been advocated as an important candidate in regulating denervation-induced muscle loss. The purpose of this article is to review the role and signaling mechanisms of apoptosis during denervation in skeletal muscle including myofibers and satellite cells.

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