IMR Press / FBL / Volume 14 / Issue 13 / DOI: 10.2741/3580

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Burns as a model of SIRS
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1 Food and Veterinary Administration, Agri-Food and Veterinary Authority of Singapore, 5 Maxwell Road, #02-03, Tower Block, MND Complex, Singapore 069110

Academic Editor: Madhav Bhatia

Front. Biosci. (Landmark Ed) 2009, 14(13), 4962–4967; https://doi.org/10.2741/3580
Published: 1 June 2009
(This article belongs to the Special Issue Animals in SIRS research)
Abstract

Thermal injury following burns is a common clinical condition. Excessive systemic inflammatory response syndrome (SIRS) following burns leads to distant organ damage and multiple organ dysfunction syndrome (MODS). Development of in vivo experimental models of burns over the past 50 years have facilitated the study of the effects of thermal injury on physiological and immunological parameters in the pathogenesis of burns and associated systemic organ damage. Using these models, researchers have established the critical role played by inflammatory mediators such as TNF-α, IL-1β, IL-6, IL-2 and substance P in burns and associated systemic organ damage. The rationale of this chapter is to present an overview of different experimental animal models, both rodents as well as large animals, of burns and associated SIRS and the role of inflammatory mediators in the pathogenesis of this condition as well as in pathogenesis of the resultant MODS.

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