IMR Press / FBL / Volume 14 / Issue 11 / DOI: 10.2741/3533

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

How the host fights against Candida infections

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1 Department of Bacteriology & Immunology, University of Helsinki, Finland
2 Helsinki University Central Hospital Laboratory Diagnostics, Helsinki, Finland
3 Department of Oral and Maxillofacial Diseases, Surgical Hospital, Helsinki University Central Hospital, Helsinki, Finland

Academic Editor: Nina Luisa Ivanovska

Front. Biosci. (Landmark Ed) 2009, 14(11), 4363–4375;
Published: 1 January 2009
(This article belongs to the Special Issue Role of IFN-gamma in immune responses to candida albicans infections)

Candida albicans is the predominant cause of both superficial and invasive forms of candidosis, although the proportion of serious infections attributed to other members of the genus is rising.. The spectrum of host defences include cell mediated immunity which is comprised of cytokine release by lymphocytes and activation of natural killer cells and lymphocytes by interleukins.. An increasing body of evidence supports a role for specific antibody in protection against invasive Candida infection. Clinical observations indicate that mucocutaneous Candida infections are commonly associated with defective cell-mediated immune responses. Innate immunity is the dominant protective mechanism against disseminated candidosis. Quantitative and qualitative abnormalities of neutrophils and monocytes are associated with systemic candidosis. In the present review virulence factors and the spectrum of immune responses are discussed in relation to the perspective for the development of appropriate vaccines against Candida. Here we present an overview of toll-like receptor signalling, cellular-dependent responses, the role of specific antibodies in protection against Candida, and the array of immune mechanisms that operate in gastrointestinal, vaginal and oral candidosis.

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