IMR Press / FBL / Volume 14 / Issue 11 / DOI: 10.2741/3523

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Mechanisms regulating S phase progression in mammalian cells
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1 Faculty of Life Sciences, University of Manchester, MIB, 131 Princess Street, Manchester, M1 7DN, UK, MRC Clinical Sciences Centre, Imperial College School of Medicine, London UK

Academic Editor: Howard Kaufman

Front. Biosci. (Landmark Ed) 2009, 14(11), 4199–4213;
Published: 1 January 2009
(This article belongs to the Special Issue Cancer vaccine)

Cell proliferation demands that identical genetic material is passed to daughter cells that form during mitosis. Genetic copies are produced during the preceding interphase, when DNA of the mother cell is copied exactly once. While few processes in biology are regulated with this precision, the fundamental importance cannot be understated as defects might compromise genetic integrity and ultimately lead to cancer. Replication of the human genome in diploid cells occurs during S phase of the cell cycle. Throughout this ~10h period, about 10% of replication units – replicons – are active at any time, even though all potential initiation sites – origins - are established before the onset of S phase. Crucially, the mechanisms that regulate origin selection and define a structured replication programme remain to be defined. We review recent progress in understanding the structure and regulation of S phase and develop a model that we believe best describes the S phase programme in human cells.

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