IMR Press / FBL / Volume 14 / Issue 11 / DOI: 10.2741/3520

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Molecular mechanisms of photodynamic therapy
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1 Section of Dermatology, University of Chicago Medical Center, 5841 South Maryland Avenue, MC-5067, Chicago, IL 60637
2 Department of Dermatology, University of Brescia, Piazzale Spedale Civile, I-25123 Brescia, Italy

Academic Editor: Peter Wolf

Front. Biosci. (Landmark Ed) 2009, 14(11), 4157–4172; https://doi.org/10.2741/3520
Published: 1 January 2009
(This article belongs to the Special Issue Molecular mechanisms of photo(chemo)therapy)
Abstract

Despite its more than 100-year history in experimental and clinical use, photodynamic therapy (PDT) is only starting to be appreciated for its full potential. PDT combines a photosensitizer (PS) and light in the presence of oxygen to treat cancer and other disorders. This manuscript reviews molecular mechanisms that have been evaluated over the past years for the effects of PDT at the cellular level as well as in therapeutic settings in vivo. The availability of multiple PS with different structures and functional properties makes PDT an extremely versatile and, conversely, a challenging approach to cancer therapy. The advancing understanding of molecular pathways helps to design improved regimens. As most cancers are being treated with combination therapies, PDT is being integrated into rationally designed combined regimens that exploit molecular responses to PDT for improved efficacy.

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