IMR Press / FBL / Volume 14 / Issue 11 / DOI: 10.2741/3518

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Protein-protein interactions and gene expression regulation in HTLV-1 infected cells
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1 Cellular and Molecular Biology Unit, FUSAGx, 5030 Gembloux, Belgium

Academic Editor: Franco Buonaguro

Front. Biosci. (Landmark Ed) 2009, 14(11), 4138–4148; https://doi.org/10.2741/3518
Published: 1 January 2009
Abstract

Human T-cell leukemia virus type 1 (HTLV-1) propagates in CD4 or CD8 T cells and, after extended latency periods of 30–50 years, causes a rapidly fatal leukemia called adult T-cell leukemia/lymphoma (ATL). Infection with HTLV-1 is also associated with a degenerative neuromuscular disease referred to as tropical spastic paraparesis or HTLV-1-associated myelopathy. HTLV genome, in addition to the structural proteins and retroviral enzymes, codes for a region at its 3 end originally designated pX. The products of this region (Tax, Rex, p12I, p13II, p30II and HBZ) play important roles in deregulation of cellular functions by either directly disrupting cellular factors or altering transcription of viral and cellular genes. Here, we will review current knowledge of protein-protein interactions that regulate transcriptional functions of proteins encoded by the pX region.

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