IMR Press / FBL / Volume 14 / Issue 11 / DOI: 10.2741/3516

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article

Cooperative production of siderophores by Pseudomonas aeruginosa

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1 Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS UK
2 Current address: Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY UK
Front. Biosci. (Landmark Ed) 2009, 14(11), 4113–4126; https://doi.org/10.2741/3516
Published: 1 January 2009
Abstract

The production of iron-scavenging siderophores by the opportunistic animal pathogen Pseudomonas aeruginosa is a textbook example of public goods cooperation. This trait provides an excellent model system with which to study cooperation. Further, the links between siderophore production and P. aeruginosa virulence allow us to investigate how pathogen ecology, social behaviour and pathology might be connected. We present here the results of basic research on the evolution and ecology of siderophore cooperation in this species. In particular, we explore the effects of population and community structure, iron regime and genomic mutation rate on the relative success of siderophore cooperators and cheats. We also present preliminary data on the links between siderophore production and another clinically-relevant social trait, biofilm formation. It is our hope that more realistic laboratory studies of siderophore cooperation in P. aeruginosa will eventually cast light on the roles played by social traits in long-term microbial infections.

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