IMR Press / FBL / Volume 14 / Issue 1 / DOI: 10.2741/3247

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Natural Tregs and autoimmunity
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1 Department of Medicine, University of California Los Angeles, 1000 Veteran Avenue 32-59, Los Angeles, California 90095-1670, USA
Academic Editor:Antonio Cava
Front. Biosci. (Landmark Ed) 2009, 14(1), 333–343;
Published: 1 January 2009
(This article belongs to the Special Issue An update on the pathogenesis of immune dysregulation in autoimmunity)

The subset of CD4+ T lymphocytes that coexpress high levels of the interleukin (IL)-2 a receptor and the transcription factor Foxp3  (CD4+CD25highFoxp3+ cells), commonly called regulatory T cells (Tregs), have a key role in the mechanisms of peripheral immune tolerance. Tregs modulate innate and adaptive immune responses in vitro and in vivo by suppressing the proliferation and cytokine production in different subsets of immune cells. Their key role in autoimmunity is suggested by the finding that reconstitution of normal numbers and/or function of Tregs in autoimmune animals associates with a delay of disease development and progression, whereas the elimination of Tregs can anticipate or precipitate disease. Since naturally occurring ("natural") Tregs represent only a small fraction of peripheral blood, the investigations for possible therapeutic use of Tregs in autoimmunity has largely focused on the use of "adaptive" Tregs, which can be induced through several different modalities. This review discusses the role of natural Tregs in the suppression of autoimmune responses and the relevance of these cells for possible therapeutic applications in autoimmunity.

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