IMR Press / FBL / Volume 13 / Issue 18 / DOI: 10.2741/3220

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Role of proteasomes in transcription and their regulation by covalent modifications
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1 Institute of Cytology, Russian Academy of Sciences, 4, Tikhoretsky ave., Saint-Petersburg, 194064, Russia
2 Molecular Oncology Research Institute, NEMC-Tufts University School of Medicine, 75 Kneeland street, Boston, 02111, USA

*Author to whom correspondence should be addressed.

Front. Biosci. (Landmark Ed) 2008, 13(18), 7184–7192; https://doi.org/10.2741/3220
Published: 1 May 2008
Abstract

The 26S proteasome is an abundant multi-subunit complex, which, in addition to lysosomes, represents a major cellular "protein degradation factory". The proteasome complex possesses protease, ATPase/helicase, and RNAse enzymatic activities, which are used by the latter to regulate various physiological processes. Recent findings have revealed an important role of proteasomes in transcriptional regulation. Although proteasomes are well documented to undergo various post-translational modifications, little is known about their functional significance, in particular in the process of gene regulation in response to various forms of stress. Here, we review the data on the role of proteasomes in gene regulation and their post-translational modifications as well as discuss potential mechanisms by which proteasomal activity may be regulated by genotoxic stress.

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