IMR Press / FBL / Volume 13 / Issue 18 / DOI: 10.2741/3215

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article

FAAP, a novel murine protein, is involved in cell adhesion through regulating vinculin-paxillin association

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1 The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The Department of Cell Biology and Genetics, College of Life Sciences
2 The Center for Theoretical Biology, Peking University, Beijing 100871, P.R. China
3 Neuroscience Research Institute; Department of Neurobiology, School of Basic Medical Sciences; Key Laboratory for Neuroscience, Ministry of Education, Key Laboratory for Neuroscience, Ministry of Public Health; Peking University, Beijing 10083, P.R. China

*Author to whom correspondence should be addressed.

Front. Biosci. (Landmark Ed) 2008, 13(18), 7123–7131; https://doi.org/10.2741/3215
Published: 1 May 2008
Abstract

Focal adhesion associated protein (FAAP), encoded by murine D10Wsu52e gene, is highly homologous to human HSPC117, which interacts with vinculin and talin. HeLa cells transfected with FAAP exhibited normal adhesion incorporation but showed impaired cell spreading, and restrained focal adhesion translocation. Moreover, FAAP facilitated vinculin-paxillin association, decreased interaction of paxillin-focal adhesion kinase and inhibited the phosphorylation of extracellular signal–regulated kinase. Together, these results suggest that FAAP, by virtue of modulating interaction of adhesion molecules, regulates cell adhesion dynamics.

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