IMR Press / FBL / Volume 13 / Issue 18 / DOI: 10.2741/3206

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Mechanisms of intestinal tight junctional disruption during infection
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1 Department of Biological Sciences, Inflammation Research Network, University of Calgary, Calgary, AB, Canada
Academic Editor:Andrei Ivanov
Front. Biosci. (Landmark Ed) 2008, 13(18), 7008–7021;
Published: 1 May 2008
(This article belongs to the Special Issue Molecular engines that build and break epithelial junctions)

Tight junctions are dynamic structures that may undergo structural and functional changes in response to both physiological and pathological circumstances. Several microbial pathogens impair intestinal barrier function by exploiting tight junctions. These pathogens have developed a broad and complex range of strategies to subvert host tight junction barrier function. The purpose of this review is to give an overview of the mechanisms whereby select enteric viruses, bacterial pathogens and parasites modulate intestinal tight junctional structure and function and how these effects may contribute to the development of chronic intestinal disorders.

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