IMR Press / FBL / Volume 13 / Issue 16 / DOI: 10.2741/3148

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Inflammatory cells in renal allografts
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1 The University of North Carolina Medical School, Department of Pathology and Laboratory Medicine, Nephropathology Unit1 , and Division of Abdominal Transplant Surgery2 , Chapel Hill, North Carolina 27599-7525, USA

*Author to whom correspondence should be addressed.

 

Front. Biosci. (Landmark Ed) 2008, 13(16), 6202–6213; https://doi.org/10.2741/3148
Published: 1 May 2008
Abstract

Renal transplants are injured by a variety of diseases and pathways. One important cause for acute and chronic graft failure is rejection. Since the advent of kidney transplantation, it has become apparent that rejection is a cellular and/or antibody mediated inflammatory process with different histologic phenotypes, and clinical degrees of severity. In recent years, the immunohistochemical detection of the complement degradation product C4d has further helped to unravel mechanisms of graft injury. Our brief review of 'renal allograft inflammation' focuses on basic morphologic aspects of rejection. Our goal is to foster the close correlation between 'histologic variants of rejection/inflammation' and molecular signalling cascades including chemokine induced effects.

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