IMR Press / FBL / Volume 13 / Issue 15 / DOI: 10.2741/3111

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


A Clinical review of deep brain stimulation and its effects on limbic basal ganglia circuitry

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1 Department of Neurology, Bichat University Hospital, 46 rue Henri Huchard, 75018 Paris, France
2 Movement Disorders Center, Departments of Neurology and Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, FL, USA

*Author to whom correspondence should be addressed.


Front. Biosci. (Landmark Ed) 2008, 13(15), 5708–5731;
Published: 1 May 2008

This paper aims to provide an overview of factors that may contribute to cognitive and mood alterations following DBS (and lesion therapy). A PubMed search based on studies in the English-language was undertaken, and included all publications on the topics of mood and surgery for movement disorders. Information was collected on preoperative and postoperative characteristics of each study, and study methodology was examined. One-hundred and forty published articles were selected and reviewed for mood and behavioral changes following neurosurgery for movement disorders. A variety of mood and cognitive changes were associated with DBS (and lesion therapy). These alterations of behavior and cognition were seen in all targets but not frequently reported with thalamic DBS. However methodological limitations, small sample sizes, lack of control groups, and the heterogeneity of data reported underscore why interpretation and comparison of limbic effects of DBS remains challenging. The collection and reporting of more standardized minimal data sets will allow for future comparisons, and improve the power required to answer many of the questions raised in this review.

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